In 1997, the Cure Autism Now (CAN) foundation established AGRE as a shared resource to accelerate the pace of biological research in the field of autism. One of its goals was to create a centralized repository of the latest findings in genetics that would help autism researchers worldwide to ask the right questions and avoid duplication of efforts.

In 2007, CAN merged with Autism Speaks to bring all efforts and programs under one voice, making AGRE part of the Autism Speaks family.  AGRE currently receives funding from Autism Speaks and the National Institute of Mental Health.

Although no longer collecting data in the home, AGRE is collaborating with outside research groups in its role as a Data Coordinating Center (DCC) to further expand the AGRE resource.  As a DCC, AGRE will continue its mission to advance autism research by maintaining a thriving DNA repository and family registry for scientists around the world.